Cydia integration. ;P No, but I'd love to see the ability to change the camera grabber back to a button, like Pre-5.1. A notification center widget store would be cool. Better iMessage.
App "profiles". In the case of GarageBand, the app is 801 megabytes. Does my iPod touch really need all 801 MB? I don't think so. A lot of apps are getting larger and larger in sizes to accommodate the new iPad's screen resolution. How about when I download an app, only the "files" that are needed for my device are downloaded. This would really help users save space on their devices.
And also a brightness slider for the multitasking bar. And mission control style multitasking would be awesome.
According to that article, the differences of iOS 6 will be the native apps. The article states that all of the built-in apps have been changed. Also, it says there will be no widgets.