I'm posting because during the course of jailbreaking/upgrading/etc. I had to completely uninstall iTunes from my Mac several times and had trouble finding this information and found it nowhere in one place. This will delete the iTunes files and the mobile device files. Problems with these files can affect iTunes ability to recognize your iPod Touch or iPhone, restore problems, and more. Everything that is deleted will be replaced by reinstalling iTunes. You can find old versions of iTunes at mac.oldapps.com. First: BACK UP ALL YOUR ITUNES MUSIC, VIDEOS, ETC. Delete all files/folders below. If it ends in ... delete all files that begin the same way as before the "...". /System/Library/Extensions/AppleMobileDevice.kext /System/Library/PrivateFrameworksMobileDevice.framework /Library/iTunes/ (if there) /Library/Receipts/AppleMobileDeviceSupport.pkg /Home/Library/iTunes/ /Home/Library/Preferences/com.apple.iTunes.... /Home/Library/Preferences/ByHost/com.apple.iTunes.... /Home/Music/iTunes/ /Applications/iTunes Now just kill iTunesHelper process with activity monitor (under applications > utilities). Then Empty Trash (may require restart to do if some files are in use). Then you're done. Just reinstall whichever version of iTunes you prefer.