Apple has just made iTunes 10.1 available to the public. This release is necessary to upgrade your iDevice’s firmware to 4.2 (if it’s ever released), and also enables AirPlay, so you can stream your media to various living-room gadgets. Slam Apple’s servers while you can!
Chpwn has deemed it safe, but proceed with caution.
I’m going out on a limb and will proclaim iTunes 10.1 perfectly safe until proven otherwise.